As the battle with COVID-19 rages around the world, a small French biotech has a possible solution for the long-term war against the virus and the rapidly spreading mutations.

The company, Valneva SE, has a vaccine that could be more variant-proof, giving it an edge over other shots in what may be an annual campaign against a disease that¡¯s already killed more than 3 million people. The first participant in its phase three trials will be dosed this week. If successful, that could lead to an approved shot in the fall.

Valneva¡¯s shot is the only candidate in clinical trials in Europe that uses a tried-and-true vaccine technology involving an inactivated version of the whole virus it¡¯s targeting. Inactivated vaccines ¡ª a century-old approach adopted for flu and polio ¡ª take a sample of the disease that has been killed and use it to stimulate an immune response without creating infection.